Multi-Dimensional Separations

A site dedicated to multi-dimensional separations with an emphasis on the liquid phase.
peak peak

Top Ten

Here are some of the classic papers in MDLC, which we consider ‘must-reads’ for anyone that engages in MDLC work.

  1. Giddings, J. C. Two-dimensional separations: concept and promise. Analytical Chemistry 56, 1258A–1270A (1984).
  2. Guiochon, G., Beaver, L. A., Gonnord, M. F., Siouffi, A. M. & Zakaria, M. Theoretical investigation of the potentialities of the use of a multidimensional column in chromatography. Journal of Chromatography A 255, 415–437 (1983).
  3. Murphy, R. E., Schure, M. R. & Foley, J. P. Effect of Sampling Rate on Resolution in Comprehensive Two-Dimensional Liquid Chromatography. Analytical Chemistry 70, 1585–1594 (1998).
  4. Schure, M. R. Limit of Detection, Dilution Factors, and Technique Compatibility in Multidimensional Separations Utilizing Chromatography, Capillary Electrophoresis, and Field-Flow Fractionation. Analytical Chemistry 71, 1645–1657 (1999).
  5. Gilar, M., Olivova, P., Daly, A. E. & Gebler, J. C. Orthogonality of Separation in Two-Dimensional Liquid Chromatography. Analytical Chemistry 77, 6426–6434 (2005).
  6. Stoll, D. R. et al. Fast, comprehensive two-dimensional liquid chromatography. Journal of Chromatography A 1168, 3–43 (2007).
  7. Guiochon, G., Marchetti, N., Mriziq, K. & Shalliker, R. Implementations of two-dimensional liquid chromatography. Journal of Chromatography A 1189, 109–168 (2008).
  8. Stoll, D. R., Wang, X. & Carr, P. W. Comparison of the Practical Resolving Power of One- and Two-Dimensional High-Performance Liquid Chromatography Analysis of Metabolomic Samples. Analytical Chemistry 80, 268–278 (2008).
  9. Malerod, H., Lundanes, E. & Greibrokk, T. Recent advances in on-line multidimensional liquid chromatography. Analytical Methods 2, 110–122 (2010).
  10. Huang, Y., Gu, H., Filgueira, M. & Carr, P. W. An experimental study of sampling time effects on the resolving power of on-line two-dimensional high performance liquid chromatography. Journal of Chromatography A 1218, 2984–2994 (2011).