Overview of 2D-LC Applications
Page:
| Application | Category | Coupling | Mode | Modulation | 1D | 2D | Detection | Reference | Year |
|---|---|---|---|---|---|---|---|---|---|
| Branched polystyrene | Polymers | on-line | comprehensive | Passive | RP-TGIC | LCCC | UV-vis | Im et al. | 2006 |
| Branched polystyrene | Polymers | on-line | comprehensive | Passive | LCCC | SEC | UV-vis | Im et al. | 2006 |
| PS-b-PMMA diblock copolymer | Polymers | on-line | comprehensive | Passive | RPLC | SEC | UV-vis | Lee et al. | 2015 |
| Therapeutic antibodies (Histidine degradation) | Biopharma | on-line | comprehensive | Passive | SEC | HILIC | MS, UV-vis | Wang et al. | 2015 |
| Metabolites (mushroom extracts) | Food | off-line | heart-cut | Manual | RPLC | RPLC | UV-vis | Pandohee et al. | 2015 |
| Antibody-drug conjugates | Biopharma | on-line | heart-cut | Passive | SEC | RPLC | UV-vis | Goyon et al. | 2018 |
| Antibody-drug conjugates | Biopharma | on-line | heart-cut | Passive | RPLC | RPLC | UV-vis | Venkatramani et al. | 2017 |
| Antibody-drug conjugates | Biopharma | on-line | heart-cut | Passive | SEC | RPLC | UV-vis | Li et al. | 2016 |
| Antibody-drug conjugates | Biopharma | on-line | heart-cut | Passive | HIC | RPLC | MS | Gilroy et al. | 2017 |
| Antibody-drug conjugates | Biopharma | on-line | comprehensive | Passive | RPLC | RPLC | MS, UV-vis | Sandra et al. | 2016 |
| Antibody-drug conjugates | Biopharma | on-line | heart-cut | Passive | RPLC | RPLC | MS, UV-vis | Sandra et al. | 2016 |
| Antibody-drug conjugates | Biopharma | on-line | comprehensive | Passive | HIC | RPLC | MS, UV-vis | Sarrut et al. | 2016 |
| Antibody-drug conjugates | Biopharma | on-line | comprehensive | Passive | HIC | SEC | MS | Ehkirch et al. | 2018 |
| Antibody-drug conjugates (free species) | Biopharma | on-line | heart-cut | Passive | SEC | RPLC | UV-vis | Li et al. | 2016 |
| Antibody-drug conjugates (free species) | Biopharma | on-line | heart-cut | Passive | MM | RPLC | MS | Birdsall et al. | 2016 |
| Biopharmaceuticals (impurities) | Biopharma | on-line | mult. heart-cut | Passive | RPLC | RPLC | MS | Petersson et al. | 2016 |
| Bovine insulin (degradants) | Biopharma | on-line | heart-cut | ASM | RPLC | RPLC | UV-vis | Stoll et al. | 2017 |
| Monoclonal antibodies | Biopharma | on-line | heart-cut | Passive | Affinity | SEC | UV-vis | Williams et al. | 2017 |
| Monoclonal antibodies | Biopharma | on-line | heart-cut | Passive | WCX | SEC | UV-vis | An et al. | 2017 |
| Monoclonal antibodies | Biopharma | on-line | comprehensive | Passive | SCX | RPLC | MS | Sorensen et al. | 2016 |
| Monoclonal antibodies | Biopharma | on-line | heart-cut | Passive | SCX | RPLC | MS | Gstöttner et al. | 2018 |
| Oligonucleotides (impurities) | Biopharma | on-line | heart-cut | SPAM | SEC | IP-RPLC | MS | Roussis et al. | 2018 |
| Oligonucleotides (impurities) | Biopharma | on-line | comprehensive | SPAM | RPLC | IP-RPLC | MS | Roussis et al. | 2018 |
| Oligonucleotides (impurities) | Biopharma | on-line | heart-cut | SPAM | SAX | IP-RPLC | MS | Roussis et al. | 2018 |
| Oligonucleotides (impurities) | Biopharma | on-line | comprehensive | SPAM | IP-RPLC | IP-RPLC | MS | Roussis et al. | 2018 |
| Therapeutic antibodies | Biopharma | on-line | heart-cut | Passive | IEX | RPLC | MS | Bathke et al. | 2018 |
| Therapeutic antibodies | Biopharma | on-line | comprehensive | ASM | HILIC | RPLC | MS | Stoll et al. | 2018 |
| Wastewater effluent (AChE inhib.) | Environmental | on-line | comprehensive | Passive | RPLC | RPLC | MS, UV-vis | Ouyang et al. | 2016 |
| Emerging contaminants | Environmental | on-line | comprehensive | Passive | RPLC | RPLC | MS | Leonhardt | 2016 |
| Polycyclic aromatics | Environmental | on-line | comprehensive | Passive | RPLC | RPLC | UV-vis | Graesbøll et al. | 2017 |
| Black chokeberries pomace | Food | on-line | comprehensive | Passive | HILIC | RPLC | MS, UV-vis | Brazdauskas et al. | 2016 |
| Overripe fruits (carotenoids) | Food | on-line | comprehensive | Passive | NPLC | RPLC | MS, UV-vis | Cacciola et al. | 2016 |
| Hop cones, pellet extracts | Food | on-line | comprehensive | Passive | RPLC | RPLC | MS, UV-vis | Sommella et al. | 2018 |
| Hop cones, pellet extracts | Food | on-line | comprehensive | Passive | HILIC | RPLC | MS, UV-vis | Sommella et al. | 2018 |
| Soybean (Kunitz Trypsin Inhibitor) | Food | off-line | heart-cut | Manual | WAX | SEC | MS | Zhou et al. | 2017 |
| Corn oil (Triacylglycerols) | Food | on-line | comprehensive | Passive | AgLC | RPLC | MS | Navarro-Reig et al. | 2016 |
| Tea, Grape seed, red wine (extracts) | Food | on-line | comprehensive | Passive | HILIC | RPLC | IMS-MS | Venter et al. | 2018 |
| Wine (polyphenols and contaminants) | Food | on-line | comprehensive | Passive | RPLC | RPLC | MS, UV-vis | Donato et al. | 2016 |
| Acyl-Coenzyme A (mouse liver) | Metabolites | on-line | heart-cut | Passive | RPLC | RPLC | MS | Wang et al. | 2017 |
| Amino acids (of gramicidin, bacitracin) | Metabolites | on-line | comprehensive | Passive | Chiral | Chiral | UV-vis | Woiwode et al. | 2018 |
| Amino acids (tea, amino acids) | Metabolites | off-line | heart-cut | Manual | RPLC | Chiral | UV-vis | Wang et al. | 2017 |
| Antioxidants (Malus hupehensis) | Metabolites | off-line | heart-cut | Manual | HILIC | RPLC | MS, UV-vis | Liu et al. | 2018 |
| Breast milk (fluoxetine, norfluoxetine) | Metabolites | on-line | heart-cut | Passive | SEC | Chiral | MS | Lopes et al. | 2018 |
| Breast milk (fluoxetine, norfluoxetine) | Metabolites | on-line | heart-cut | Passive | SEC | RPLC | MS | Alvim-Jr. et al. | 2016 |
| Flavonoids | Metabolites | off-line | heart-cut | Manual | HILIC | RPLC | MS | Yao et al. | 2017 |
| Flavonoids | Metabolites | on-line | comprehensive | Passive | RPLC | RPLC | UV-vis | Corgier et al. | 2016 |
| Flavonoids from licorice | Metabolites | off-line | heart-cut | Manual | NPLC | RPLC | MS, UV-vis | Fan et al. | 2016 |
| Furanocoumarins | Metabolites | on-line | comprehensive | Passive | RPLC | RPLC | UV-vis | Cook et al. | 2017 |
| Lipidomics (brain tissue) | Metabolites | on-line | heart-cut | SPAM | HILIC | RPLC | MS | Berkecz et al. | 2018 |
| Lipidomics (human plasma) | Metabolites | on-line | heart-cut | VEM | NPLC | RPLC | MS | Shen et al. | 2017 |
| Lipidomics (mice serum) | Metabolites | on-line | heart-cut | VEM | NPLC | RPLC | MS | Weng et al. | 2016 |
| Lipidomics (rat plasma) | Metabolites | off-line | heart-cut | Manual | MM | RPLC | MS | Narváez-Rivas et al. | 2017 |
| Lipidomics (cyanobacteria) | Metabolites | on-line | heart-cut | VEM | NPLC | RPLC | MS | Shan et al. | 2016 |
| Lipidomics (human plasma) | Metabolites | on-line | comprehensive | Passive | RPLC | HILIC | MS | Baglai et al. | 2017 |
| Lipids (rice) | Metabolites | on-line | comprehensive | Passive | RPLC | HILIC | MS | Navarro-Reig et al. | 2018 |
| Metabolites (Escherichia coli) | Metabolites | on-line | comprehensive | Passive | RPLC | RPLC | MS, UV-vis | Cacciola et al. | 2018 |
| Metabolites (green cocoa beans) | Metabolites | on-line | comprehensive | SPAM | HILIC | RPLC | MS, UV-vis | Toro-Uribe et al. | 2018 |
| Metabolites (licorice) | Metabolites | on-line | comprehensive | Passive | HILIC | RPLC | MS, UV-vis | Montero et al. | 2016 |
| Metabolites (microbial) | Metabolites | on-line | comprehensive | SPAM | RPLC | RPLC | UV-vis | Yan et al. | 2016 |
| Metabolites (Panax notoginseng leaves) | Metabolites | off-line | comprehensive | Manual | HILIC | RPLC | MS, UV-vis | Yao et al. | 2018 |
| Metabolites (rice plant) | Metabolites | on-line | comprehensive | Passive | HILIC | RPLC | MS | Navarro-Reig et al. | 2017 |
| Metabolites (Vitamin D, human serum) | Metabolites | on-line | heart-cut | SPAM | RPLC | RPLC | MS | Mena-Bravo et al. | 2016 |
| Metabolites and lipids (human plasma) | Metabolites | on-line | heart-cut | Passive | RPLC | RPLC | MS | Wang et al. | 2017 |
| Metabolomics (Glycyrrhiza glabra) | Metabolites | on-line | comprehensive | Passive | RPLC | RPLC | MS, UV-vis | Wong et al. | 2018 |
| Phenolic acids | Metabolites | on-line | comprehensive | EMM | RPLC | RPLC | UV-vis | Fornells et al. | 2018 |
| Phenolic acids and flavonoids | Metabolites | on-line | comprehensive | Passive | MM | RPLC | UV-vis | Hájek et al. | 2016 |
| Phenolic compounds (Grapevine canes) | Metabolites | on-line | comprehensive | Passive | HILIC | RPLC | MS, UV-vis | Montero et al. | 2018 |
| Plant extracts and coffee | Metabolites | on-line | heart-cut | Passive | RPLC | RPLC | MS | Stephan et al. | 2016 |
| Polyphenols | Metabolites | on-line | comprehensive | SPAM | HILIC | RPLC | MS | Sommella et al. | 2017 |
| Polyphenols in red raspberry fruits shoots | Metabolites | on-line | comprehensive | Passive | RPLC | RPLC | MS | Kula et al. | 2016 |
| Procyanidins (cocoa) | Metabolites | on-line | comprehensive | Passive | HILIC | RPLC | UV-vis | Muller et al. | 2018 |
| Proteinogenic amino acids | Metabolites | on-line | heart-cut | Passive | RPLC | Chiral | UV-vis | Woiwode et al. | 2018 |
| Steroids | Metabolites | on-line | comprehensive | Passive | TRLC | RPLC | UV-vis | Baert et al. | 2018 |
| Testosterone (human serum) | Metabolites | on-line | heart-cut | Passive | RPLC | RPLC | MS | Vamethevan et al. | 2016 |
| Urine (bovine) | Metabolites | on-line | comprehensive | SPAM | RPLC | RPLC | MS | Baglai et al. | 2018 |
| Urine (Steroids, Sulphonamides) | Metabolites | on-line | comprehensive | Passive | RPLC | RPLC | MS | Blokland et al. | 2018 |
| Bioactives in plant extracts | Miscellaneous | on-line | comprehensive | SPAM | RPLC | RPLC | ELSD | Coulerie et al. | 2016 |
| Heavy-oil fractions | Miscellaneous | on-line | comprehensive | Passive | NA-RPLC | NA-RPLC | CAD, UV-vis | van Beek et al. | 2018 |
| Household dust and dryer lint | Miscellaneous | on-line | comprehensive | Passive | RPLC | RPLC | MS | Ouyang et al. | 2017 |
| Lignin phenols | Miscellaneous | on-line | comprehensive | SPAM | RPLC | SFC | UV-vis | Sun et al. | 2018 |
| Synthetic cannabinoids | Miscellaneous | on-line | comprehensive | Passive | RPLC | RPLC | MS | Eckberg et al. | 2018 |
| Synthetic dyes | Miscellaneous | on-line | comprehensive | Passive | SAX | IP-RPLC | UV-vis | Pirok et al. | 2016 |
| Tobacco | Miscellaneous | on-line | heart-cut | SPAM | SCX | RPLC | MS | Shao et al. | 2017 |
| Tobacco (snus) | Miscellaneous | on-line | heart-cut | Passive | RPLC | RPLC | MS | Gi et al. | 2017 |
| Vacuum-gas oil fraction | Miscellaneous | on-line | comprehensive | SPAM | RPLC | RPLC | MS | Jakobsen et al. | 2017 |
| Phlorotannins in brown algae | Natural medicines | on-line | comprehensive | Passive | HILIC | RPLC | MS, UV-vis | Sánchez-Camargo et al. | 2016 |
| Brown seaweed | Natural medicines | on-line | comprehensive | Passive | HILIC | RPLC | MS, UV-vis | Montero et al. | 2016 |
| TCM (Additives) | Natural medicines | on-line | heart-cut | SPAM | Affinity | RPLC | UV-vis | Guo et al. | 2017 |
| TCM (Dracocephalum heterophyllium) | Natural medicines | off-line | heart-cut | Manual | RPLC | HILIC | MS, NMR | Dang et al. | 2018 |
| TCM (U. rhynchophylla) | Natural medicines | off-line | heart-cut | Manual | MM | MM | UV-vis | Wei et al. | 2016 |
| TCM (Curcuma kwangsiensis) | Natural medicines | on-line | comprehensive | Passive | RPLC | RPLC | MS | Zhou et al. | 2018 |
| TCM (Flos Carthami, dried flowers) | Natural medicines | on-line | comprehensive | SPAM | MM | RPLC | UV-vis | Wang et al. | 2017 |
| TCM (Gardenia jasminoides Ellis) | Natural medicines | off-line | comprehensive | Manual | RPLC | HILIC | MS | Zhou et al. | 2017 |
| TCM (Gegen-Qinlian Decoction) | Natural medicines | on-line | comprehensive | Passive | RPLC | RPLC | MS | Qiao et al. | 2016 |
| TCM (Notoginseng total saponins) | Natural medicines | off-line | comprehensive | Manual | HILIC | RPLC | MS | Yang et al. | 2016 |
| TCM (Oxytropis falcata) | Natural medicines | off-line | heart-cut | Manual | RPLC | RPLC | UV-vis | Wang et al. | 2017 |
| TCM (Salvia miltiorrhiza) | Natural medicines | off-line | comprehensive | Manual | HILIC | RPLC | MS | Sun et al. | 2016 |
| TCM (Salvia miltiorrhiza) | Natural medicines | on-line | comprehensive | Passive | RPLC | RPLC | MS | Cao et al. | 2016 |
| TCM (sapinins and alkaloids) | Natural medicines | off-line | heart-cut | Manual | RPLC | RPLC | MS | Jin et al. | 2018 |
| TCM (saponins in Gleditsia sinensis) | Natural medicines | on-line | comprehensive | Passive | RPLC | RPLC | MS | Wang et al. | 2016 |
| TCM (Sphaerophysa salsula) | Natural medicines | off-line | heart-cut | Manual | RPLC | HILIC | NMR,UV-vis | Jiao et al. | 2017 |
| TCM (toad skin) | Natural medicines | off-line | comprehensive | Manual | NPLC | RPLC | MS | Zhang et al. | 2016 |
| TCM (Tropane alkaloids) | Natural medicines | on-line | heart-cut | Passive | RPLC | SCX | UV-vis | Long et al. | 2018 |
| TCM (Xuebijing) | Natural medicines | on-line | heart-cut | Passive | RPLC | RPLC | MS, UV-vis | Lin et al. | 2018 |
| TCM (Zhibai Dihuang Granule) | Natural medicines | off-line | comprehensive | Manual | SCX | RPLC | MS | Liu et al. | 2018 |
| TCM (Denzhan Shenmai) | Natural medicines | off-line | comprehensive | Passive | RPLC | RPLC | MS | Sheng et al. | 2017 |
| TCM (Denzhan Shenmai) | Natural medicines | on-line | heart-cut | Passive | RPLC | Chiral | MS | Sheng et al. | 2017 |
| TCM (Ginseng powder) | Natural medicines | on-line | heart-cut | Passive | HILIC | RPLC | UV-vis | Ji et al. | 2016 |
| TCM (Ginkgo biloba) | Natural medicines | off-line | comprehensive | Passive | HILIC | RPLC | MS | Ji et al. | 2017 |
| Peptide biomarkers (rat urine) | Peptides | off-line | heart-cut | Manual | RPLC | RPLC | MS | Zhang et al. | 2018 |
| Peptic digests | Peptides | on-line | heart-cut | SPAM | RPLC | MM | MS | Saleh et al. | 2016 |
| Peptides | Peptides | on-line | comprehensive | Passive | RPLC | RPLC | MS, UV-vis | Sarrut et al. | 2017 |
| Protein digests (plasma) | Peptides | off-line | heart-cut | Manual | RPLC | RPLC | MS | Yang et al. | 2018 |
| Tryptic peptides | Peptides | on-line | heart-cut | SPAM | SCX | RPLC | MS | Kwiatkowski et al. | 2018 |
| Tryptic peptides (Cortical neurons) | Peptides | on-line | comprehensive | SPAM | SCX | RPLC | MS | Chuang et al. | 2018 |
| Tryptic peptides (Elaeis Guineensis Jacq) | Peptides | on-line | heart-cut | SPAM | RPLC | RPLC | MS | Nascimento et al. | 2018 |
| Tryptic peptides (Flammulina velutipes) | Peptides | off-line | heart-cut | Manual | RPLC | RPLC | MS | Fang et al. | 2017 |
| Tryptic peptides (human tissue, cancer) | Peptides | on-line | heart-cut | Passive | RPLC | RPLC | MS | Lee et al. | 2016 |
| Tryptic peptides (mitochondrial proteins) | Peptides | off-line | heart-cut | Manual | SCX | RPLC | MS | Li et al. | 2018 |
| Tryptic peptides (lung adenocarcinoma) | Peptides | off-line | heart-cut | Manual | SCX | RPLC | MS | Li et al. | 2018 |
| Tryptic peptides (proteus mirabilis) | Peptides | off-line | heart-cut | Manual | RPLC | RPLC | MS | Dong et al. | 2018 |
| Tryptic peptides (Salmonella bacteria) | Peptides | off-line | heart-cut | Manual | SCX | RPLC | MS | Sun et al. | 2018 |
| Tryptic peptides (serum) | Peptides | off-line | heart-cut | Manual | SCX | RPLC | MS | Sun et al. | 2017 |
| Tryptic peptides (serum) | Peptides | off-line | heart-cut | Manual | SCX | RPLC | MS | Ye et al. | 2017 |
| Peptides | Peptides | on-line | comprehensive | Passive | RPLC | SEC | UV-vis | Xu et al. | 2018 |
| Peptides | Peptides | on-line | heart-cut | Passive | Chiral | RPLC | FLD, MS | Cheng et al. | 2018 |
| Peptides | Peptides | on-line | heart-cut | Passive | Chiral | Affinity | FLD, MS | Cheng et al. | 2018 |
| Peptides | Peptides | on-line | comprehensive | Passive | SEC | RPLC | UV-vis | Xu et al. | 2017 |
| Peptides | Peptides | on-line | heart-cut | Passive | RPLC | RPLC | MS, UV-vis | Luo et al. | 2017 |
| Antibiotic drug (cefonicid sodium) | Pharmaceuticals | on-line | heart-cut | Passive | RPLC | RPLC | MS | Wang et al. | 2017 |
| Antibiotic residues in dairy products | Pharmaceuticals | on-line | heart-cut | Passive | HILIC | RPLC | MS | Wang et al. | 2017 |
| Antibiotics | Pharmaceuticals | on-line | heart-cut | Passive | RPLC | RPLC | MS | Wang et al. | 2017 |
| Beta-blockers in human plasma | Pharmaceuticals | on-line | heart-cut | Passive | SEC | RPLC | FLD | Gonçalves et al. | 2017 |
| Desonide cream | Pharmaceuticals | on-line | heart-cut | Passive | RPLC | RPLC | MS | Wang et al. | 2018 |
| Parental drug microdosing vehicle | Pharmaceuticals | on-line | heart-cut | Passive | RPLC | RPLC | MS, UV-vis | Dai et al. | 2017 |
| Pharmaceutical materials | Pharmaceuticals | on-line | heart-cut | Passive | RPLC | RPLC | MS, UV-vis | Yang et al. | 2017 |
| Pharmaceuticals | Pharmaceuticals | on-line | selective compr. | Passive | RPLC | SFC | UV-vis | Iguiniz et al. | 2018 |
| Pharmaceuticals | Pharmaceuticals | on-line | comprehensive | Passive | Chiral | Chiral | UV-vis | Barhate et al. | 2017 |
| Pharmaceuticals | Pharmaceuticals | on-line | heart-cut | Passive | RPLC | Chiral | UV-vis | Barhate et al. | 2017 |
| Pharmaceuticals | Pharmaceuticals | on-line | heart-cut | SPAM | RPLC | SFC | MS, UV-vis | Venkatramani et al. | 2016 |
| Pharmaceuticals | Pharmaceuticals | on-line | comprehensive | Passive | RPLC | RPLC | MS, UV-vis | Iguiniz et al. | 2018 |
| Pharmaceuticals, Metabolites | Pharmaceuticals | on-line | heart-cut | SPAM | RPLC | Chiral | MS | Goel et al. | 2018 |
| Therapeutic drug (in human plasma) | Pharmaceuticals | on-line | heart-cut | SPAM | RPLC | RPLC | UV-vis | Sheng et al. | 2017 |
| Vidarabine monophosphate | Pharmaceuticals | on-line | heart-cut | SPAM | RPLC | MM | MS | Wang et al. | 2017 |
| Vitamins | Pharmaceuticals | on-line | heart-cut | ASM | HILIC | RPLC | UV-vis | Bäurer et al. | 2018 |
| Oligomers (Oxidzed waxes) | Polymers | on-line | comprehensive | Passive | NPLC | SEC | ELSD | Ndiripo et al. | 2018 |
| Polyether polyols | Polymers | on-line | comprehensive | Passive | HILIC | RPLC | MS | Groeneveld et al. | 2018 |
| Polymeric nanoparticles | Polymers | on-line | comprehensive | SPAM | HDC | SEC | UV-vis | Pirok et al. | 2017 |
| Synthetic polymers (Polystyrene/ Polybutadiene Block Copolymers) | Polymers | on-line | comprehensive | SPAM | NA-TGIC | SEC | UV-vis | Lee et al. | 2018 |
| Synthetic polymers (Polystyrene/ Polybutadiene Block Copolymers) | Polymers | on-line | comprehensive | SPAM | RP-TGIC | LCCC | UV-vis | Lee et al. | 2018 |
| Synthetic polymers (novolac) | Polymers | on-line | comprehensive | ASM | SEC | RPLC | UV-vis | Pursch et al. | 2018 |
| Synthetic polymers (branched poly (bisphenol-A-carbonate)) | Polymers | on-line | comprehensive | Passive | LCCC | SEC | LS, RID, UV-vis, VI | Apel et al. | 2018 |
| Synthetic polymers (HEUR) | Polymers | on-line | comprehensive | Passive | SEC | RPLC | ELSD | Yang et al. | 2018 |
| Synthetic polymers (non-linear) | Polymers | on-line | comprehensive | Passive | NPLC | SEC | LS, RID, VI | Lee et al. | 2016 |
| Synthetic polymers (poloxamers) | Polymers | on-line | comprehensive | Passive | LCCC | LCCC | ELSD | Malik et al. | 2016 |
| Synthetic polymers (polystyrene) | Polymers | on-line | comprehensive | Passive | NA-RPLC | SEC | UV-vis | Urban et al. | 2017 |
| Intact histone proteoforms | (Intact) Proteins | on-line | comprehensive | SPAM | MM | RPLC | MS | Gargano et al. | 2018 |
| Intact proteins | (Intact) Proteins | on-line | comprehensive | Passive | SCX | RPLC | UV-vis | Lynch et al. | 2018 |
| Intact proteins and protein digests | (Intact) Proteins | on-line | comprehensive | Passive | SCX | IP-RPLC | MS, UV-vis | Vonk et al. | 2015 |
| Metaproteomics (soil) | (Intact) Proteins | on-line | heart-cut | SPAM | SCX | RPLC | MS | Callister et al. | 2018 |
| Proteins in human plasma | (Intact) Proteins | on-line | comprehensive | SPAM | SAX | RPLC | None | Huang et al. | 2016 |
| Ethoxylate phosphate surfactants | Surfactants | on-line | comprehensive | SPAM | HILIC | RPLC | UV-vis | Gargano et al. | 2016 |
| Ionic surfactants | Surfactants | on-line | comprehensive | Passive | MM | RPLC | CAD | Pirok et al. | 2018 |
| Non-ionic surfactants in pharmaceuticals | Surfactants | on-line | comprehensive | Passive | HILIC | RPLC | ELSD, MS | 2018 | |
| Polymeric dispersants in detergents | Surfactants | on-line | heart-cut | Passive | SEC | RPLC | ELSD | Yang et al. | 2018 |
| Pyrrolizidine alkaloids | Metabolites | on-line | heart-cut | Passive | RPLC | RPLC | MS | van de Schans et al. | 2017 |
| Lipidomics | Metabolites | on-line | comprehensive | Passive | RPLC | HILIC | MS | Holčapek et al. | 2015 |
| TCM | Natural medicines | off-line | heart-cut | Manual | SCX | RPLC | MS | Jiang et al. | 2015 |
| Fish oil (Triacylglycerol) | Food | on-line | comprehensive | Stop-flow | AgLC | NA-RPLC | ELSD, MS | Beccaria et al. | 2015 |
| Proteins from mouse adipose tissue | (Intact) Proteins | off-line | comprehensive | Manual | SCX | RPLC | MS | Sajic et al. | 2015 |
| Cannabinoids | Natural medicines | on-line | heart-cut | Passive | RPLC | RPLC | MS, Other | Pandohee et al. | 2015 |
| Dye extracts | Miscellaneous | on-line | comprehensive | SPAM | SAX | RPLC | MS, UV-vis | Pirok et al. | 2019 |
| Charged acrylic polymeric particles | Polymers | on-line | comprehensive | SPAM | SEC | SEC | UV-vis | Pirok et al. | 2019 |
| Pharmaceutical drugs | Pharmaceuticals | on-line | comprehensive | Passive | RPLC | RPLC | MS, UV-vis | Iguiniz et al. | 2019 |
| Pharmaceutical drugs | Pharmaceuticals | on-line | heart-cut | Passive | RPLC | WAX | MS | Long et al. | 2019 |
| Phenolic compounds | Metabolites | on-line | comprehensive | Passive | HILIC | RPLC | UV-vis | Jandera et al. | 2019 |
| Natural phenolics in Rooibos tea, Grape seed | Food | on-line | comprehensive | FSM | HILIC | RPLC | MS | Muller et al. | 2019 |
| Panax ginseng root extract in saponin | Traditional Chinese medicine | on-line | comprehensive | Passive | RPLC | HILIC | UV-vis | Chen et al. | 2019 |
| Phenolic compounds in pomegranate | Food | on-line | comprehensive | Passive | RPLC | RPLC | MS, UV-vis | Russo et al. | 2019 |
| Pistacia vera L. kernel extracts | Food | on-line | comprehensive | Passive | RPLC | RPLC | MS | Arena et al. | 2019 |
| Prebiotic oligosaccharides | Food | on-line | comprehensive | SPAM | HILIC | RPLC | UV-vis | Martín-Ortiz et al. | 2019 |
| Proteins in eggs | Food | on-line | comprehensive | SPAM | SEC | RPLC | MS | Melfi et al. | 2019 |
| Synthetic polymers (bimodal high-density polyethylene) | Polymers | on-line | comprehensive | Passive | RPLC | SEC | ELSD | Prabhu et al. | 2015 |
| TCM (ginsenosides in Panax ginseng) | Natural medicines | off-line | comprehensive | Manual | HILIC | RPLC | MS | Qiu et al. | 2015 |
| Lipidomics (mice serum) | Metabolites | on-line | heart-cut | VEM | NPLC | RPLC | MS | Weng et al. | 2015 |
| Monoclonal antibodies (rituximab) | Biopharma | on-line | selective compr. | Passive | CEX | RPLC | MS | Stoll et al. | 2015 |
| Benzophenones (transformation products) | Environmental | on-line | mult. heart-cut | Passive | RPLC | BMC | Li et al. | 2015 | |
| Natural polymers (carboxymethyl celluloses) | Polymers | on-line | comprehensive | Passive | RPLC | SEC | ELSD | Shakun et al. | 2015 |
| Metabolites (Pichia pastoris) | Metabolites | on-line | heart-cut | Passive | RPLC | RPLC | MS | Ortmayr et al. | 2015 |
| HBCD Isomersin PS Foam | Polymers | on-line | mult. heart-cut | Passive | RPLC | RPLC | UV-vis | Pursch et al. | 2015 |
| Peptides (Saccharomyces cerevisiae digest) | Peptides | on-line | comprehensive | SPAM | SCX | RPLC | MS | Vonk et al. | 2015 |
| Synthetic polymers (polystyrene block copolymers) | Polymers | on-line | comprehensive | Passive | RPLC | SEC | ELSD | Wright et al. | 2015 |
| Metabolites | Metabolites | on-line | comprehensive | Passive | RPLC | RPLC | MS | Willmann et al. | 2015 |
| Aflatoxins (Aspergillus sp.) | Food | on-line | heart-cut | Passive | RPLC | RPLC | MS | Breidbach et al. | 2015 |
| Yoghurt (food additives) | Food | on-line | heart-cut | Stop-flow | RPLC | RPLC | UV-vis | Hou et al. | 2015 |
| Ramelteon (human serum) | Pharmaceuticals | on-line | heart-cut | Passive | RPLC | RPLC | UV-vis | Sagirli et al. | 2015 |
| Phospholipids | Food | on-line | heart-cut | Passive | HILIC | RPLC | MS | Sun et al. | 2015 |
| Phosphatidylcholine isomers | Food | on-line | heart-cut | Passive | HILIC | RPLC | MS | Sun et al. | 2014 |
| Therapeutic antibodies | Biopharma | on-line | comprehensive | Passive | RPLC | RPLC | MS, UV-vis | Vanhoenacker et al. | 2015 |
| Wastewater effluent (toxicants) | Environmental | on-line | comprehensive | Passive | RPLC | RPLC | MS, UV-vis | Ouyang et al. | 2015 |
| Peptides (from milk) | Food | on-line | comprehensive | Passive | RPLC | RPLC | UV-vis | Sommella et al. | 2015 |
| TCM (Tripterygium wilfordii Hook.f) | Natural medicines | on-line | comprehensive | Passive | RPLC | RPLC | MS | Qu et al. | 2015 |
| TCM (triterpenoid saponins) | Natural medicines | on-line | heart-cut | Stop-flow | HILIC | RPLC | MS | Wang et al. | 2015 |
| TCM (Carthamus tinctorius L.) | Natural medicines | off-line | comprehensive | Manual | HILIC | RPLC | MS | Yang et al. | 2015 |
| TCM (Panax notoginseng saponins) | Natural medicines | on-line | mult. heart-cut | Passive | RPLC | RPLC | UV-vis | Yao et al. | 2015 |
| Dairy products (Proteins and additives) | Food | on-line | heart-cut | Stop-flow | RPLC | RPLC | UV-vis | Hou et al. | 2015 |
| Flavonoids and iridoid glycosides in Hedyotis diffusa | Natural medicines | on-line | comprehensive | Passive | RPLC | RPLC | MS, UV-vis | Li et al. | 2015 |
| Antibody-drug conjugates (free species) | Biopharma | on-line | heart-cut | Passive | SEC | RPLC | MS, UV-vis | Li et al. | 2015 |
| Pharmaceuticals (naproxen and degradants) | Pharmaceuticals | on-line | comprehensive | Passive | RPLC | RPLC | UV-vis | Stoll et al. | 2015 |
| Glycated albumin (digest) | Peptides | on-line | heart-cut | SPAM | Affinity | RPLC | MS | Pepaj et al. | 2015 |
| Tryptic digests | Peptides | on-line | comprehensive | Passive | RPLC | RPLC | UV-vis | Sarrut et al. | 2015 |
| Wastewater effluent (pharmaceuticals and pesticides) | Environmental | on-line | comprehensive | Passive | RPLC | RPLC | MS | Leonhardt et al. | 2015 |
| Carboxilic acids | Metabolites | on-line | comprehensive | Passive | RPLC | RPLC | UV-vis | Stoll et al. | 2015 |
| TCM (bufadienolides in toad skin) | Natural medicines | off-line | comprehensive | Manual | NPLC | RPLC | MS | Zhang et al. | 2015 |
| TCM (antioxidants in Ginkgo biloba extract) | Natural medicines | on-line | comprehensive | Passive | RPLC | RPLC | UV-vis | Guo et al. | 2015 |
| TCM (Hypericum ascyron extract) | Natural medicines | on-line | heart-cut | Passive | RPLC | RPLC | UV-vis | Li et al. | 2015 |
| Red chili pepper (caretenoids) | Food | on-line | comprehensive | Passive | NPLC | RPLC | MS, UV-vis | Mondello et al. | 2014 |
| Pharmaceutical drugs | Pharmaceuticals | on-line | heart-cut | Passive | RPLC | RPLC | MS, UV-vis | Venkatramani et al. | 2014 |
| Vancomycin in plasma | Pharmaceuticals | on-line | heart-cut | SPAM | RPLC | RPLC | UV-vis | Li et al. | 2014 |
| Anthocyanins in blue berries, red radish, cabbage and black beans | Food | off-line | comprehensive | Passive | HILIC | RPLC | MS | Willemse et al. | 2014 |
| White wine and TCM | Food | on-line | comprehensive | Passive | MM | RPLC | UV-vis | Li et al. | 2014 |
| Neurotransmitters | Metabolites | on-line | heart-cut | Passive | RPLC | RPLC | MS, Other | Holland et al. | 2014 |
| Tryptic digest (endogenous PSA) | Peptides | on-line | heart-cut | SPAM | HILIC | RPLC | MS | Simon et al. | 2014 |
| Phosphatidylcholine isomers in cell membranes | Miscellaneous | on-line | heart-cut | Passive | HILIC | RPLC | MS | Sun et al. | 2014 |
| poly(styrene)-co-poly(methyl methacrylate)latex | Polymers | on-line | comprehensive | Passive | RPLC | SEC | UV-vis | Schoenmakers et al. | 2014 |
| Synthetic polymers (polystyrene) | Polymers | on-line | comprehensive | Passive | NPLC | SEC | UV-vis | Jeong et al. | 2014 |
| Synthetic polymers (polysorbate) | Polymers | on-line | heart-cut | Passive | MM | RPLC | UV-vis | Li et al. | 2014 |
| Bio-oil (organic acids) | Miscellaneous | on-line | comprehensive | Passive | RPLC | RPLC | MS | Le Masle et al. | 2014 |
| Oligonucleotides | Miscellaneous | off-line | comprehensive | Manual | IP-RPLC | CE | UV-vis | Porebski | 2014 |
| Milk powder (carbohydrates) | Food | on-line | heart-cut | SPAM | RPLC | RPLC | RID | Ma et al. | 2014 |
| Sugar phosphates in yeast cells | Metabolites | on-line | heart-cut | Passive | SAX | RPLC | MS | Klavins et al. | 2014 |
| Polycyclic aromatic compounds | Miscellaneous | on-line | comprehensive | Passive | RPLC | RPLC | UV-vis | Græsbøll et al. | 2014 |
| Corn seed, Gingo Biloba and valerian root | Natural medicines | on-line | heart-cut | SPAM | RPLC | RPLC | UV-vis | Allen et al. | 2014 |
| Polycyclic aromatic hydrocarbons | Miscellaneous | on-line | comprehensive | Passive | RPLC | RPLC | UV-vis | Place et al. | 2014 |
| Synthetic polymers (poly(propylene) copolymers) | Polymers | on-line | comprehensive | Passive | RPLC | SEC | ELSD | Cheruthazhekatt et al. | 2014 |
| Pharmaceutical drugs | Pharmaceuticals | on-line | heart-cut | Passive | RPLC | RPLC | UV-vis | Shackman et al. | 2014 |
| Phenolic antioxidants | Food | on-line | comprehensive | Passive | HILIC | RPLC | Other, UV-vis | Kalili et al. | 2014 |
| TCM (Radix et Rhizoma Asari) | Natural medicines | on-line | heart-cut | SPAM | Affinity | RPLC | MS | Han et al. | 2014 |
| Sugarcane leaf (polyphenols) | Food | on-line | comprehensive | Passive | RPLC | RPLC | MS | Leme et al. | 2014 |
| TCM (P. lobata) | Natural medicines | on-line | comprehensive | Passive | RPLC | RPLC | MS, UV-vis | Qiao et al. | 2014 |
| Lipidomics (human plasma) | Metabolites | on-line | heart-cut | VEM | NPLC | RPLC | MS | Li et al. | 2014 |
| Milk powder (flavonoids) | Food | on-line | heart-cut | SPAM | RPLC | RPLC | UV-vis | Ma et al. | 2014 |
| Fatty alcohol ethoxylates | Surfactants | on-line | heart-cut | Passive | RPLC | RPLC | UV-vis | Escrig-Doménech et al. | 2014 |
| Brown algae (phlorotannins) | Food | on-line | comprehensive | Passive | HILIC | RPLC | MS, UV-vis | Montero et al. | 2014 |
| Synthetic polymers (ethylene/1‐octene copolymers) | Polymers | on-line | comprehensive | Passive | RPLC | SEC | ELSD | Mekab et al. | 2014 |
| Lipidomics (human plasma) | Metabolites | on-line | comprehensive | Stop-flow | HILIC | RPLC | MS | Wang et al. | 2013 |
| Furanocoumarins | Metabolites | on-line | comprehensive | Passive | RPLC | RPLC | UV-vis | Tran et al. | 2013 |
| Red wine | Food | on-line | comprehensive | Passive | MM | RPLC | UV-vis | Matos et al. | 2013 |
| Wastewater effluent (contaminants) | Environmental | on-line | comprehensive | Passive | RPLC | RPLC | MS | Haun et al. | 2013 |
| Apples (phenolic compounds) | Food | on-line | comprehensive | Passive | HILIC | RPLC | MS, UV-vis | Montero et al. | 2013 |
| Synthetic polymers (tacticity of Poly(Methyl Methacrylates)) | Polymers | on-line | comprehensive | Passive | RPLC | SEC | ELSD | Maiko et al. | 2013 |
| Phospholipids | Metabolites | on-line | heart-cut | Passive | SAX | RPLC | MS | Bang et al. | 2013 |
| Grape Seed | Food | on-line | comprehensive | Passive | HILIC | RPLC | MS | Kalili et al. | 2013 |
| Pharmaceuticals (enantiomeric excess) | Pharmaceuticals | on-line | heart-cut | Passive | NPLC | Chiral | UV-vis | Liu et al. | 2013 |
| Tryptic digest (BSA, lysozyme and myoglobine) | Peptides | on-line | comprehensive | Passive | RPLC | RPLC | UV-vis | D'Attoma et al. | 2013 |
| Lipidomics (porcine brain) | Metabolites | off-line | heart-cut | Manual | HILIC | RPLC | MS | Cífková et al. | 2013 |
| Synthetic polymers (cellulose acetates) | Polymers | off-line | heart-cut | Manual | NPLC | SEC | ELSD | Ghareeb et al. | 2013 |
| Tartary buckwheat | Natural medicines | on-line | heart-cut | Passive | RPLC | RPLC | UV-vis | Ren et al. | 2013 |
| Synthetic polymers (high-density polyethylene) | Polymers | on-line | comprehensive | Passive | RPLC | SEC | ELSD | Ginzburg et al. | 2013 |
| TCM (Hedyotis diffusa) | Natural medicines | on-line | comprehensive | Passive | RPLC | RPLC | MS, UV-vis | Li et al. | 2013 |
| Lipidomics (human plasma) | Metabolites | on-line | heart-cut | VEM | NPLC | RPLC | MS | Li et al. | 2013 |
| Pesticide residues | Food | on-line | heart-cut | SPAM | HILIC | RPLC | MS | Kittlaus et al. | 2013 |
| Synthetic polymers (RAFT polymerization) | Polymers | on-line | comprehensive | Passive | LCCC | SEC | ELSD | Keddie et al. | 2013 |
| TCM (Amide alkaloids in Piper longumL.) | Natural medicines | off-line | comprehensive | Passive | NPLC | RPLC | MS | Li et al. | 2013 |
| Cocoa (procyanidins) | Food | on-line | comprehensive | Passive | HILIC | RPLC | FLD, UV-vis | 10.1016/j.chroma.2013.03.009 | 2013 |
| Synthetic polymers (polypropylene copolymers) | Polymers | on-line | comprehensive | Passive | NA-RPLC | SEC | ELSD | Cheruthazhekatt et al. | 2013 |
| Synthetic polymers (functionalized polyolefins) | Polymers | on-line | comprehensive | Passive | NA-RPLC | SEC | ELSD | Ginzburg et al. | 2013 |
| Pesticides | Food | on-line | heart-cut | SPAM | HILIC | RPLC | MS | Kittlaus et al. | 2013 |
| Phospholipids | Metabolites | on-line | comprehensive | Stop-flow | HILIC | RPLC | MS | Dugo et al. | 2013 |
| Apiaceous vegetables (furanocoumarins) | Food | on-line | selective compr. | Passive | RPLC | RPLC | UV-vis | Larson et al. | 2013 |
| Tryptic digest (porcine circovirus type 2) | Peptides | off-line | heart-cut | Manual | SCX | RPLC | MS | Liu et al. | 2013 |
| Peanut oil (triacylglycerols) | Food | off-line | comprehensive | Manual | NA-RPLC | AgLC | MS | Hu et al. | 2013 |
| Tryptic digest (antiviral factors) | Peptides | off-line | heart-cut | Manual | SCX | RPLC | MS | Tong et al. | 2013 |
| Pharmaceutical drugs | Pharmaceuticals | on-line | heart-cut | Passive | RPLC | Chiral | UV-vis | Lee et al. | 2013 |
| Fatty alcohol derivatives | Surfactants | on-line | comprehensive | Passive | HILIC | RPLC | MS | Elsner et al. | 2012 |
| Phenolic compounds | Metabolites | on-line | comprehensive | Passive | HILIC | RPLC | UV-vis | Jandera et al. | 2012 |
| Synthetic polymers (protonated and deuterated polystyrene) | Polymers | on-line | comprehensive | Passive | LCCC | SEC | ELSD | Sinha et al. | 2012 |
| Tryptic digest (Gly m 4 Protein) | Peptides | on-line | heart-cut | SPAM | SAX | RPLC | MS, UV-vis | Julka et al. | 2012 |
| Pharmaceutical drugs | Pharmaceuticals | off-line | comprehensive | Manual | RPLC | HILIC | CAD, MS | Schiesel | 2012 |
| Synthetic polymers (poly(ethylene oxide)) | Polymers | on-line | comprehensive | Passive | RPLC | SEC | NMR | Hiller et al. | 2012 |
| Histone post-translational modifications | (Intact) Proteins | off-line | heart-cut | Manual | MM | RPLC | MS | Tian et al. | 2012 |
| Tryptic digest (scorpion Buthus martensi Karsch venom) | Peptides | off-line | heart-cut | Manual | RPLC | HILIC | MS | Xu et al. | 2012 |
| Synthetic polymers (Poly(styrene‑b‑isoprene) Miktoarm StarCopolymers) | Polymers | on-line | comprehensive | Manual | RPLC | SEC | ELSD, UV-vis | Ljubič et al. | 2012 |
| Synthetic polymers (PMMA and polyurethanes) | Polymers | on-line | comprehensive | Passive | RPLC | SEC | ELSD, UV-vis | Uliyanchenko et al. | 2012 |
| Tryptic digest (host cell protein impurities) | Peptides | off-line | heart-cut | Manual | RPLC | RPLC | MS | Schenauer et al. | 2012 |
| Synthetic oligonucleotides | Pharmaceuticals | on-line | comprehensive | Passive | HILIC | RPLC | MS | Li et al. | 2012 |
| Maize seeds | Food | on-line | comprehensive | Passive | RPLC | RPLC | UV-vis | Allen et al. | 2012 |
| TCM (Anemarrhena asphodeloides, steroid glycoside) | Natural medicines | on-line | comprehensive | Passive | RPLC | RPLC | MS | Liu et al. | 2012 |
| Tryptic digest (Methylocellasilvestris) | Peptides | on-line | heart-cut | Passive | RPLC | RPLC | MS | Patel et al. | 2012 |
| TCM (Qingkailing) | Natural medicines | on-line | selective compr. | Passive | RPLC | RPLC | MS, UV-vis | Ma et al. | 2012 |
| Natural organic matter | Environmental | on-line | comprehensive | Passive | HILIC | SEC | ELSD, FLD, UV-vis | Duarte et al. | 2012 |
| Natural organic matter | Environmental | on-line | comprehensive | Passive | RPLC | SEC | ELSD, FLD, UV-vis | Duarte et al. | 2012 |
| Tryptic digest (Bacillus thuringiensis) | Peptides | on-line | heart-cut | SPAM | SCX | RPLC | MS | Huang et al. | 2012 |
| Natural antioxidants | Metabolites | off-line | heart-cut | Manual | RPLC | MEKC | UV-vis | Česla et al. | 2012 |
| TCM (Radix Angelica sinensis) | Natural medicines | on-line | comprehensive | Passive | RPLC | RPLC | MS | Dück et al. | 2012 |
| D‐/L‐phenylalanine | Pharmaceuticals | on-line | heart-cut | Passive | RPLC | Chiral | UV-vis | Venkatramani et al. | 2012 |
| D‐/L‐phenylalanine | Pharmaceuticals | on-line | comprehensive | Passive | RPLC | Chiral | UV-vis | Venkatramani et al. | 2012 |
| Organic acids (aromatics and flavanoids) | Metabolites | on-line | comprehensive | Passive | RPLC | RPLC | UV-vis | Hájek et al. | 2012 |
| Shotgun proteomics | Peptides | on-line | heart-cut | SPAM | HILIC | RPLC | MS | Zhao et al. | 2012 |
| Rooibos tea (phenolics) | Food | on-line | comprehensive | Passive | HILIC | RPLC | UV-vis | Beelders et al. | 2012 |
| TCM (Stevia Rebaudiana) | Natural medicines | off-line | comprehensive | Manual | RPLC | HILIC | MS | Fu et al. | 2012 |
| Synthetic polymers (polystyrene-polyethylene oxide block copolymers) | Polymers | on-line | comprehensive | Passive | LCCC | SEC | ELSD | Malik et al. | 2012 |
| TCM (Panax notoginseng saponins) | Natural medicines | off-line | comprehensive | Manual | HILIC | RPLC | MS, UV-vis | Xing et al. | 2012 |
| Peanut oil and mouse tissue (triacylglycerides) | Lipids | on-line | heart-cut | Passive | AgLC | RPLC | MS | Yang et al. | 2012 |
| Synthetic polymers (Branched Polymers) | Polymers | on-line | comprehensive | Passive | RP-TGIC | SEC | LS, RI, VI | Ahn et al. | 2012 |
| Synthetic polymers (Poly(styrene-block-t-butyl methacrylate) Copolymers) | Polymers | on-line | comprehensive | Passive | RPLC | SEC | ELSD | Ljubič et al. | 2012 |
| Synthetic polymers (Poly(styrene-block-t-butyl methacrylate) Copolymers) | Polymers | on-line | comprehensive | Passive | LCCC | SEC | ELSD | Ljubič et al. | 2012 |
| Tryptic digest (neutrophils) | Peptides | off-line | heart-cut | Manual | SCX | RPLC | MS | Trusch et al. | 2012 |
| Synthetic polymers (PDMS-PS block copolymers) | Polymers | off-line | comprehensive | Passive | LCCC | SEC | ELSD, UV-vis | Malik et al. | 2012 |
| Endocrine disrupting compounds in water | Environmental | on-line | heart-cut | Passive | RPLC | RPLC | MS | David Matějíček | 2012 |
| Corn seed | Metabolites | on-line | comprehensive | Passive | RPLC | RPLC | UV-vis | Paek et al. | 2012 |
| Tryptic digest (rat brain) | Peptides | off-line | heart-cut | Manual | RPLC | WCX | MS | Cai et al. | 2012 |
| Maize seed extract | Food | on-line | comprehensive | Passive | RPLC | RPLC | UV-vis | Zhang et al. | 2012 |
| Wastewater effluent (cocaince) | Environmental | on-line | selective compr. | Passive | RPLC | RPLC | MS | Groskreutz et al. | 2012 |
| Opiates | Pharmaceuticals | on-line | selective compr. | Passive | RPLC | RPLC | UV-vis | Groskreutz et al. | 2012 |
| Taxanes | Pharmaceuticals | on-line | heart-cut | Passive | HILIC | RPLC | MS | Rezadoost et al. | 2012 |
| Licorice (liquiritin) | Food | off-line | comprehensive | Passive | RPLC | RPLC | UV-vis | Cong et al. | 2012 |
| Synthetic polymers (polypropylene Copolymers) | Polymers | on-line | comprehensive | Passive | RPLC | SEC | ELSD | Cheruthazhekatt et al. | 2012 |
| Organic acids | Metabolites | on-line | comprehensive | Passive | RPLC | RPLC | UV-vis | Duarte et al. | 2012 |
| TCM (Scutellaria barbata D. Don) | Natural medicines | off-line | comprehensive | Manual | HILIC | RPLC | MS, UV-vis | Liang et al. | 2012 |
| TCM (Scutellaria barbata D. Don) | Natural medicines | off-line | comprehensive | Passive | HILIC | HILIC | MS, UV-vis | Liang et al. | 2012 |
| Tryptic digest (phosphorylated peptides) | Peptides | off-line | heart-cut | Manual | RPLC | RPLC | MS | Stephanowitz et al. | 2012 |
| Green and black tea (Camellia sinensis, phenolics) | Food | off-line | comprehensive | Manual | SEC | RPLC | ELSD, UV-vis | Scoparo et al. | 2012 |
| Tryptic digest (serum) | Peptides | off-line | heart-cut | Manual | SCX | RPLC | MS | Zhang et al. | 2012 |
| TCM (flavanoids) | Natural medicines | off-line | heart-cut | Manual | RPLC | RPLC | MS | Zeng et al. | 2012 |
| Monoclonal antibodies | Biopharma | on-line | heart-cut | SPAM | RPLC | RPLC | MS | Doneanu | 2012 |
| Alkylphenol polyethoxylates | Surfactants | on-line | comprehensive | Passive | HILIC | RPLC | MS | Wu et al. | 2011 |
| Monoclonal antibodies | Biopharma | on-line | heart-cut | SPAM | MM | RPLC | MS, UV-vis | Alvarez et al. | 2011 |
| Maize extract | Food | on-line | comprehensive | Passive | RPLC | RPLC | UV-vis | Filgueira et al. | 2011 |
| Synthetic polymers (poly(2-ethyl-2-oxazoline) copolymers) | Polymers | on-line | comprehensive | Passive | LCCC | SEC | Baumgaertel et al. | 2011 | |
| TCM | Natural medicines | off-line | heart-cut | SPAM | RPLC | HILIC | UV-vis | Cao et al. | 2011 |
| Synthetic polymers (poly(ethylene-co-propylene)) | Polymers | on-line | comprehensive | Passive | RPLC | SEC | IR, LS, RI | Lee et al. | 2011 |
| Synthetic polymers (polystyrene) | Polymers | off-line | comprehensive | Manual | SEC | HDC | UV-vis | Uliyanchenko et al. | 2011 |
| Maize extract | Food | on-line | comprehensive | Passive | RPLC | RPLC | UV-vis | Gu et al. | 2011 |
| Hydroxypropylmethylcellulose (HPMC) | Polymers | on-line | comprehensive | Passive | RPLC | SEC | CAD | Greuderer et al. | 2011 |
| Lipidomics (egg, soya, porcine brain) | Metabolites | off-line | heart-cut | Manual | HILIC | NA-RPLC | MS | Lísa et al. | 2011 |
| Myoglobin, serum albumin, pepstatin, proteinase inhibitor | (Intact) Proteins | on-line | heart-cut | SPAM | SCX | RPLC | MS, UV-vis | Julka et al. | 2011 |
| River water (pollutants in Monjolinho River) | Environmental | on-line | heart-cut | Passive | Affinity | Chiral | MS | Barreiro et al. | 2011 |
| Tryptic digest (Trypsin, bovine serum, ovalbumin, lysozyme, hemoglobin) | Peptides | on-line | heart-cut | Passive | WAX | RPLC | UV-vis | Li et al. | 2011 |
| Estrogens in sediments | Environmental | on-line | heart-cut | Passive | RPLC | RPLC | MS | DavidMatějíček | 2011 |
| Synthetic polymers (polyolefins) | Polymers | on-line | comprehensive | Passive | RPLC | SEC | ELSD | Ginzburg et al. | 2011 |
| Borago officinalis oil (triacylglycerols) | Lipids | on-line | comprehensive | Passive | AgLC | NA-RPLC | ELSD | Mondello et al. | 2011 |
| Flavones in Citrus juices | Food | on-line | comprehensive | Passive | RPLC | RPLC | UV-vis | Russo et al. | 2011 |
| Peptides | Peptides | on-line | heart-cut | Passive | RPLC | CE | MS | Chambers et al. | 2011 |
| Metabolites (Saccharomyces cerevisae) | Metabolites | off-line | comprehensive | Manual | SCX | HILIC | MS | Fairchild et al. | 2010 |
| Non-ionic surfactants (Polysorbates, Tween) | Surfactants | on-line | comprehensive | Passive | LCCC | HILIC | ELSD | Abrar et al. | 2010 |
| Block copolymers | Polymers | on-line | heart-cut | Passive | LCD | SEC | ELSD | Berek et al. | 2010 |
| Phospholipids (plasma) | Lipids | on-line | heart-cut | Manual | WAX | RPLC | MS | Sato et al. | 2010 |
| Synthetic polymers (2-ethylhexyl acrylate and methyl acrylate RAFT) | Polymers | on-line | comprehensive | Passive | SEC | LCCC | ELSD | Raust et al. | 2010 |
| Antibody-drug conjugates | Biopharmaceuticals | on-line | heart-cut | Passive | Affinity | RPLC | MS | Murphy et al. | 2010 |
| Synthetic polymers (thylene-vinylacetate copolymers) | Polymers | on-line | comprehensive | Passive | NPLC | SEC | ELSD | Ginzburg et al. | 2010 |
| Low-molar-mass organic acids | Food | on-line | comprehensive | Passive | SAX | RPLC | UV-vis | Brudin et al. | 2010 |
| espresso coffees (ristretto, decaffeinatto, volluto) | Food | on-line | comprehensive | Passive | RPLC | RPLC | Other, UV-vis | Mnatsakanyan et al. | 2010 |
| Lipidomics (rat serum) | Metabolites | on-line | heart-cut | VEM | NPLC | RPLC | MS | Nie et al. | 2010 |
| Anti-PEG Antibody digest | Peptides | on-line | heart-cut | Passive | SCX | RPLC | MS | Xu et al. | 2010 |
| Coal tar | Miscellaneous | on-line | heart-cut | VEM | NPLC | RPLC | UV-vis | Ding et al. | 2010 |
| arctiin in fruit (Arctium lappa L.) | Food | on-line | heart-cut | Passive | CCC | RPLC | UV-vis | Guo et al. | 2010 |
| omeprazole in waste and estuarine water | Environmental | on-line | heart-cut | Passive | Affinity | Chiral | MS | Barreiro et al. | 2010 |
| TCM (Herba Hedyotis Diffusae) | Natural medicines | off-line | comprehensive | Manual | RPLC | HILIC | UV-vis | Feng et al. | 2010 |
| TCM (platycosides in Platycodi Radix) | Natural medicines | on-line | comprehensive | Passive | RPLC | RPLC | MS | Jeong et al. | 2010 |
| Antibody tryptic digests | Peptides | on-line | heart-cut | Passive | Affinity | RPLC | MS, UV-vis | Cho et al. | 2010 |
| Phenolic acids and flavones | Food | on-line | comprehensive | Passive | RPLC | RPLC | UV-vis | Jandera et al. | 2010 |
| Tryptic digest (pertussis toxoid) | Peptides | off-line | heart-cut | Manual | RPLC | RPLC | MS | Tummala et al. | 2010 |
| Synthetic polymers (fatty alcohol ethoxylates) | Polymers | on-line | comprehensive | Passive | RPLC | NPLC | ELSD | Raust et al. | 2010 |
| Chiral enantiomers (amino acids in irradiated foodstuffs) | Food | on-line | heart-cut | Passive | RPLC | Chiral | Guillén-Casla et al. | 2010 | |
| Human plasma protein | Peptides | off-line | heart-cut | Manual | SCX | RPLC | MS | Ahrends et al. | 2010 |
| TCM (Corydalis yanhusuo, antinociceptive components) | Natural medicines | on-line | comprehensive | Passive | RPLC | RPLC | MS, UV-vis | Wang et al. | 2010 |
| Drug metabolites in urine | Metabolites | on-line | heart-cut | SPAM | RPLC | RPLC | MS | Jayamanne et al. | 2010 |
| Synthetic polymers (polyoxyalkylene block copolymers) | Polymers | off-line | heart-cut | Manual | LCCC | SEC | MS | Malik et al. | 2010 |
| Synthetic polymers (Polysorbates) | Polymers | on-line | comprehensive | Passive | NPLC | LCCC | ELSD | Trathnigg et al. | 2010 |
| Cr-enriched yeast | Miscellaneous | off-line | heart-cut | Manual | SEC | RPLC | MS | Kaewkhomdee et al. | 2010 |
| TCM (Rheum Palmatum L) | Natural medicines | off-line | comprehensive | Manual | RPLC | RPLC | UV-vis | Xue et al. | 2009 |
| Whey protein hydrolysate | Peptides | on-line | comprehensive | Passive | RPLC | RPLC | UV-vis | Bedani et al. | 2009 |
| Polyphenols in red wines | Food | on-line | comprehensive | Passive | RPLC | RPLC | MS, UV-vis | Mondello et al. | 2009 |
| Polyphenolic antioxidants in red wine | Food | on-line | comprehensive | Passive | RPLC | RPLC | MS, UV-vis | Dugo et al. | 2008 |
| Tryptic digest (transferrin, BSA, alcohol dehydrogenase, lysozyme, cytochrome c, beta-casein, mAb) | Peptides | on-line | comprehensive | Passive | SCX | RPLC | MS, UV-vis | Eeltink et al. | 2009 |
| TCM (Zhengtian pills) | Natural medicines | on-line | comprehensive | Stop-flow | NPLC | RPLC | UV-vis | Wei et al. | 2009 |
| Polyphenols in mate extracts | Food | on-line | comprehensive | Passive | RPLC | RPLC | MS, UV-vis | Dugo et al. | 2009 |
| Tryptic digest (Human Glioblastoma Multiforme Tissue) | Peptides | off-line | heart-cut | Manual | SCX | IP-RPLC | MS | Melchior | 2009 |
| Recombinant antibody-related drugs (rAbs) | Peptides | on-line | heart-cut | Passive | Affinity | RPLC | UV-vis | Zhang et al. | 2009 |
| Synthetic polymers (Caprolactone) | Polymers | off-line | comprehensive | Manual | LCCC | RPLC | ELSD | Ahmed et al. | 2009 |
| Taxanes in Taxus baccata L. | Natural medicines | on-line | heart-cut | Passive | RPLC | RPLC | UV-vis | Ghassempour et al. | 2009 |
| Epoxy resins | Polymers | on-line | comprehensive | Passive | SEC | LCCC | MS, UV-vis | Julka et al. | 2009 |
| Complex polymers (PS-b-PI-b-PS triblock copolymer, mikto arm block copolymer) | Polymers | on-line | comprehensive | Passive | SEC | NPLC | UV-vis | Im et al. | 2009 |
| Complex polymers (PS-b-PI-b-PS triblock copolymer, mikto arm block copolymer) | Polymers | on-line | comprehensive | Passive | RP-TGIC | SEC | UV-vis | Im et al. | 2009 |
| Cytochrome c, myoglobin, ribonuclease A, lysozyme, alpha-amylase, alpha-chymotrypsin, insulin | (Intact) Proteins | on-line | mult. heart-cut | Passive | HIC | WCX | MS | Geng et al. | 2009 |
| Antioxidants | Metabolites | on-line | comprehensive | Passive | RPLC | RPLC | UV-vis | Česla et al. | 2009 |
| Active pharmaceutical ingredients (API) and degradants | Pharmaceuticals | on-line | comprehensive | Passive | RPLC | RPLC | UV-vis | Alexander et al. | 2009 |
| TCM (Fructus aurantii, flavones) | Natural medicines | off-line | heart-cut | Manual | RPLC | RPLC | MS, UV-vis | Zhou et al. | 2009 |
| Tryptic digest (BSA, cytochrome c, beta-casein, myoglobin and lysozyme) | Peptides | off-line | heart-cut | Manual | SCX | RPLC | MS | Wang et al. | 2009 |
| Flavonol glycosides from leaves of Maytenus ilicifolia | Natural medicines | off-line | comprehensive | Manual | SEC | RPLC | MS | de Souza et al. | 2009 |
| TCM (Carthamus tinctorius Linn.) | Natural medicines | off-line | heart-cut | Manual | RPLC | HILIC | UV-vis | Liu et al. | 2008 |
| Manganese binding to biomolecules in pine nuts | Food | off-line | heart-cut | Manual | SEC | RPLC | Arias-Borrego et al. | 2008 | |
| Synthetic polymers (Polystyrene‐block‐Polyisoprene Diblock Copolymers) | Polymers | on-line | comprehensive | Passive | LCCC | SEC | ELSD | Mass et al. | 2008 |
| Synthetic polymers ((meth)acrylate-based copolymers) | Polymers | on-line | comprehensive | Passive | NA-RPLC | SEC | ELSD | Raust et al. | 2008 |
| Sulphonated lignins | Polymers | on-line | comprehensive | Passive | IP-RPLC | SEC | Brudin et al. | 2008 | |
| Phenolic compounds in beverages | Food | on-line | comprehensive | Passive | RPLC | RPLC | Kivilompolo et al. | 2008 | |
| Synthetic polymers (branched polymers) | Polymers | on-line | comprehensive | Passive | MTF | SEC | UV-vis | Edam et al. | 2008 |
| Protein extracts | (Intact) Protein | off-line | heart-cut | Manual | IEF | RPLC | UV-vis | Suberbielle et al. | 2008 |
| 2-acetyl-4-(1,2,3,4-tetrahydroxybutyl)imidazole in Class III caramel colours | Food | on-line | heart-cut | Passive | RPLC | RPLC | UV-vis | Moretton et al. | 2008 |
| TCM (Lobelia chinensis Lour.) | Natural medicines | off-line | heart-cut | Manual | RPLC | RPLC | MS, UV-vis | Zhou et al. | 2008 |
| TCM (Radix salviae miltiorrhiza bage) | Natural medicines | on-line | comprehensive | VEM | NPLC | RPLC | MS | Tian et al. | 2008 |
| Carotenoids in Red Orange Oil | Food | on-line | comprehensive | Passive | NPLC | RPLC | MS, UV-vis | Dugo et al. | 2008 |
| Alprazolam | Pharmaceuticals | off-line | comprehensive | Manual | RPLC | RPLC | UV-vis | Huidobro et al. | 2008 |
| Tryptic digest (cytochrome C, lysozyme C, alcohol dehydrogenase, BSA, serotransferrin) | Peptides | on-line | heart-cut | SPAM | SCX | RPLC | Hesse et al. | 2008 | |
| Phenolic acids | Metabolites | on-line | comprehensive | Passive | RPLC | RPLC | UV-vis | Jandera et al. | 2008 |
| Antioxidant phenols in wine and juice | Food | on-line | comprehensive | Passive | RPLC | RPLC | UV-vis | Kivilompolo et al. | 2008 |
| Peptides in milk hydrolysates | Food | off-line | heart-cut | Manual | RPLC | HILIC | MS | Platerink et al. | 2008 |
| Pharmaceuticals in urine | Pharmaceuticals | on-line | comprehensive | Passive | RPLC | RPLC | MS, UV-vis | Eggink et al. | 2008 |
| Tryptic digest (myoglobin and BSA) | Peptides | off-line | comprehensive | Manual | SCX | RPLC | UV-vis | Marchetti et al. | 2008 |
| TCM (Swertia franchetiana Smith) | Natural medicines | off-line | heart-cut | Manual | RPLC | RPLC | MS | Liu et al. | 2008 |
| Polyphenols | Metabolites | on-line | comprehensive | Passive | RPLC | RPLC | UV-vis | Jandera et al. | 2008 |
| TCM (saponins from Quillaja saponaria) | Natural medicines | on-line | comprehensive | Passive | HILIC | HILIC | MS | Wang et al. | 2008 |
| Lemon oil extract | Food | on-line | comprehensive | Passive | NPLC | RPLC | François et al. | 2008 | |
| Triacylglycerols in corn oil | Food | on-line | comprehensive | Passive | AgLC | RPLC | ELSD, MS, UV-vis | van der Klift et al. | 2008 |
| Active components in licorice | Food | on-line | heart-cut | Passive | RPLC | RPLC | UV-vis | Cong et al. | 2008 |
| Taxus baccata L. | Natural medicines | on-line | heart-cut | Passive | RPLC | RPLC | UV-vis | Ghassempour et al. | 2008 |
| Corn seed powder extract | Metabolites | on-line | comprehensive | Passive | RPLC | RPLC | UV-vis | Stoll et al. | 2008 |
| TCM (Magnolia biondii, lignans) | Natural medicines | on-line | heart-cut | Passive | RPLC | RPLC | UV-vis | Zhao et al. | 2007 |
| High intensity sweeteners in plants | Food | on-line | comprehensive | Passive | RPLC | RPLC | MS | Pól et al. | 2007 |
| High intensity sweeteners in plants | Food | on-line | comprehensive | Passive | SCX | RPLC | MS | Pól et al. | 2007 |
| Polyphenols in beverages | Food | on-line | comprehensive | SPAM | RPLC | RPLC | UV-vis | Cacciola et al. | 2007 |
| Tryptic digest (HepG2 proteome) | Peptides | on-line | heart-cut | Passive | SCX | RPLC | MS | Yamashita et al. | 2007 |
| TCM (Flos Lonicera) | Natural medicines | on-line | comprehensive | Passive | SAX | RPLC | MS, UV-vis | Chen et al. | 2007 |
| Tryptic digest (cytochrome c) | Peptides | on-line | heart-cut | Passive | SCX | RPLC | MS | Liu et al. | 2007 |
| Apo A‐I in human plasma | (Intact) Proteins | on-line | heart-cut | SPAM | RPLC | SAX | UV-vis | Pepaj et al. | 2007 |
| Antioxidant phenolic acids in Lamiaceae herbs | Food | on-line | comprehensive | Passive | RPLC | RPLC | MS | Kivilompolo et al. | 2007 |
| excreta (feces or urine) extracts from rats or mice | Metabolites | off-line | heart-cut | Manual | RPLC | RPLC | MS, UV-vis | Kiffe et al. | 2007 |
| Tryptic digest (cell lysate) | Peptides | off-line | heart-cut | Manual | HILIC | RPLC | Boersema et al. | 2007 | |
| Metabolites in urine | Metabolites | off-line | heart-cut | Manual | RPLC | RPLC | MS | Trunzer et al. | 2007 |
| Synthetic polymers (PS-b-PI diblock copolymer) | Polymers | on-line | comprehensive | SPAM | NP-TGIC | NA-RPLC | UV-vis | Im et al. | 2007 |
| TCM (Angelica dahurica) | Natural medicines | on-line | heart-cut | VEM | NPLC | RPLC | UV-vis | Tian et al. | 2006 |
| BioZate3 | Peptides | on-line | comprehensive | Stop-flow | SEC | RPLC | MS, UV-vis | Bedani et al. | 2006 |
| Phenolic antioxidants | Food | on-line | comprehensive | SPAM | RPLC | RPLC | UV-vis | Cacciola et al. | 2006 |
| Tryptic digest (proteins extracted from normal human liver tissue) | Peptides | on-line | heart-cut | Passive | SCX | RPLC | MS | Gu et al. | 2006 |
| Acidic compounds in atmospheric aerosols | Environmental | on-line | comprehensive | Passive | SCX | RPLC | MS | Pól et al. | 2006 |
| Synthetic polymers (poly(ethylene glycol)-poly(vinyl acetate) graft copolymers) | Polymers | on-line | comprehensive | Passive | LCCC | SEC | ELSD | Knecht et al. | 2006 |
| Poly(bisphenol A)carbonate and polymers | Polymers | on-line | comprehensive | Passive | LCCC | SEC | IR | Coulier et al. | 2006 |
| Synthetic polymers (Linear and 3‐Arm Star Block Copolymers) | Polymers | on-line | comprehensive | Passive | LCCC | SEC | ELSD | Gao et al. | 2006 |
| TCM (Adinandra nitida) | Natural medicines | on-line | comprehensive | Passive | RPLC | RPLC | MS, UV-vis | Zhang et al. | 2006 |
| TCM (Qingkailing) | Natural medicines | off-line | comprehensive | Manual | SEC | RPLC | UV-vis | Ma et al. | 2006 |
| Biomarkers in rat plasma | Peptides | off-line | heart-cut | Passive | IEF | RPLC | MS | Linke et al. | 2006 |
| Indoles in wild-type maize seed extracts | Metabolomics | on-line | comprehensive | Passive | SCX | RPLC | UV-vis | Porter et al. | 2006 |
| Tryptic digest (bovine serum albumin, BSA) | Peptides | on-line | comprehensive | Passive | SCX | RPLC | UV-vis | Stoll et al. | 2005 |
| Synthetic polymers (thylene oxide–propylene oxide (co)oligomers) | Polymers | on-line | comprehensive | Passive | RPLC | HILIC | ELSD | Jandera et al. | 2006 |
| Selenium species in aqueous extracts of alfalfa sprouts | Metabolites | off-line | comprehensive | Passive | SEC | IP-RPLC | ICP-MS | Gergely et al. | 2006 |
| Triacylglycerols | Lipids | on-line | comprehensive | Passive | AgLC | NA-RPLC | MS | Dugo et al. | 2006 |
| Triacylglycerols in milk | Food | on-line | comprehensive | Passive | AgLC | NA-RPLC | MS | Dugo et al. | 2006 |
| Tryptic digest (plant tissues) | Peptides | on-line | comprehensive | Passive | HPCF | RPLC | MS | Pirondini et al. | 2006 |
| Synthetic polymers (poly(bisphenol A)carbonate, degraded) | Polymers | on-line | comprehensive | Passive | LCCC | SEC | IR, MS | Coulier et al. | 2006 |
| Polyphenols | Food | on-line | comprehensive | Passive | NPLC | RPLC | UV-vis | Dugo et al. | 2006 |
| Synthetic polymers (styrene-methylacrylate (SMA) copolymers) | Polymers | on-line | comprehensive | Passive | RPLC | SEC | IR, UV-vis | Kok et al. | 2005 |
| Triacylglycerol in food | Lipids | on-line | comprehensive | Passive | AgLC | NA-RPLC | MS, UV-vis | Mondello et al. | 2005 |
| Tryptic digest (C. elegans) | Peptides | on-line | heart-cut | SPAM | SCX | RPLC | MS | Tschäppät et al. | 2005 |
| Synthetic polymers (poly(bisphenol A)carbonate) | Polymers | on-line | comprehensive | Passive | NPLC | SEC | UV-vis | Coulier et al. | 2005 |
| Synthetic polymers (poly(bisphenol A)carbonate) | Polymers | on-line | comprehensive | Passive | LCCC | SEC | UV-vis | Coulier et al. | 2005 |
| Organic acids | Metabolites | on-line | comprehensive | Passive | RPLC | MM | UV-vis | Venkatramani et al. | 2005 |
| Tryptic digest (D20) | Peptides | on-line | heart-cut | SPAM | RPLC | SCX | MS | Wang et al. | 2005 |
| Synthetic polymers (poly(methyl methacrylate)) | Polymers | on-line | comprehensive | Passive | LCCC | SEC | ELSD, UV-vis | Jiang et al. | 2005 |
| Synthetic polymers (n-butyloligostyrenes) | Polymers | on-line | heart-cut | Passive | RPLC | RPLC | UV-vis | Gray et al. | 2005 |
| Tryptic digest (26S and 20S proteasome) | Peptides | off-line | heart-cut | Manual | SCX | RPLC | MS | Fujii et al. | 2004 |
| Tryptic digest (PUMA-Induced Apoptosis samples) | Peptides | on-line | heart-cut | Passive | SCX | RPLC | MS | Gu et al. | 2004 |
| Tryptic digest (saliva proteome) | Peptides | off-line | heart-cut | Manual | SCX | RPLC | MS | Wilmarth et al. | 2004 |
| Tryptic digest (human serum proteins) | Peptides | off-line | heart-cut | Manual | RPLC | CE | MS | Janini et al. | 2004 |
| TCM (Rhizoma chuanxiong) | Natural medicines | on-line | comprehensive | Passive | RPLC | RPLC | MS, UV-vis | Chen et al. | 2004 |
| Oligoalanine peptide stereoisomers | Peptides | on-line | heart-cut | Passive | RPLC | Chiral | MS | Czerwenka et al. | 2004 |
| Clerodendrum floribundum | Natural medicines | on-line | heart-cut | Passive | RPLC | RPLC | UV-vis | Wong et al. | 2004 |
| Synthetic polymers (PLA/PDMS graft terpolymers) | Polymers | on-line | comprehensive | Passive | LCCC | SEC | ELSD | Lutz et al. | 2004 |
| Tryptic digests (A431) | Peptides | on-line | heart-cut | Passive | SCX | RPLC | MS | Chelius et al. | 2003 |
| Synthetic polymers (poly(methyl methacrylate)) | Polymers | on-line | comprehensive | Passive | RPLC | SEC | ELSD | Siewing et al. | 2003 |
| Tryptic digest (bovine proteins) | Peptides | on-line | heart-cut | Passive | SCX | RPLC | MS | Nägele et al. | 2003 |
| Aromatic and non-aromatic amines | Metabolites | on-line | comprehensive | Passive | RPLC | RPLC | UV-vis | Venkatramani et al. | 2003 |
| Synthetic polyemers (polystyrene, PMMA) | Polymers | on-line | comprehensive | Passive | NA-RPLC | SEC | UV-vis | van der Horst et al. | 2003 |
| Triacylglycerides in edible oils and fats | Lipids | off-line | comprehensive | Manual | AgLC | GC | FID | Janssen et al. | 2003 |
| Triacylglycerides in edible oils and fats | Lipids | off-line | comprehensive | Manual | NPLC | GC | FID | Janssen et al. | 2003 |
| Tryptic digest (Caenorhabditis elegans) | Peptides | on-line | heart-cut | SPAM | SCX | RPLC | MS | Mawuenyega et al. | 2003 |
| Synthetic polymers (styrene-butadiene and butyl rubber) | Polymers | on-line | comprehensive | Passive | NA-RPLC | SEC | ELSD | Heinz et al. | 2003 |
| Tryptic digest (protein mixtures) | Peptides | on-line | heart-cut | SPAM | SCX | RPLC | MS | Qiu et al. | 2002 |
| Selenium-containing biomolecules from yeast extracts | Peptides | off-line | heart-cut | Manual | SEC | RPLC | ICP-MS | Lindemann et al. | 2002 |
| Synthetic polymers (polystyrene) | Polymers | on-line | heart-cut | SPAM | RPLC | RPLC | UV-vis | Sweeney and Shalliker | 2002 |
| Fatty acid polyglycol ethers | Surfactants | on-line | heart-cut | SPAM | LCCC | RPLC | ELSD, RI | Trathnigg et al. | 2002 |
| Cell extracts (proteins, metabolites) | (Intact) Proteins | off-line | comprehensive | Manual | RPLC | CE | UV-vis | He et al. | 2002 |
| Biological matrices (incl pecan nut, straw, mouse plasma) | Miscellaneous | on-line | heart-cut | Passive | RPLC | RPLC | MS | Pascoe et al. | 2001 |
| Synthetic polymers (EPDM polymers with grafted methyl methacrylate) | Polymers | on-line | comprehensive | Passive | LCCC | NA-RPLC | ELSD, UV-vis | Siewing et al. | 2001 |
| Proteins from human breast cancer whole cell lysates | (Intact) Proteins | off-line | heart-cut | Manual | HPCF | RPLC | MS | Chong et al. | 2001 |
| Selenium speciation in selenized yeast extracts | (Intact) Proteins | off-line | heart-cut | Manual | SEC | RPLC | ICP-MS | McSheehy et al. | 2001 |
| Proteins (mixture) | (Intact) Proteins | on-line | comprehensive | Passive | SCX | RPLC | MS, UV-vis | Wagner et al. | 2000 |
| JP-TS jet fuel | Energy carriers | on-line | comprehensive | Thermal | GC | GC | FID | Fraga et al. | 2000 |
| t,t-muconic acid in human urine | Metabolites | on-line | heart-cut | SPAM | RPLC | RPLC | UV-vis | Serena et al. | 2000 |
| Fatty alcohol ethoxylates | Polymers | on-line | heart-cut | Passive | LCC | SEC | ELSD | Trathnigg et al. | 1999 |
| Alcohol Ethoxylates | Surfactants | on-line | comprehensive | Passive | NPLC | RPLC | ELSD | Murphy et al. | 1998 |
| Tryptic digest (BSA) | Peptides | on-line | heart-cut | Passive | SEC | RPLC | MS | Opiteck et al. | 1998 |
| Tryptic digests (ovalbumin and serum albumin) | Peptides | on-line | comprehensive | Passive | SEC | RPLC | MS | Opiteck et al. | 1997 |
| Escherichia coli cell lysate | Proteins | on-line | comprehensive | Passive | SCX | RPLC | MS, UV-vis | Opiteck et al. | 1997 |
| fluorescein 5-isothiocyanate (FITC)-labeled phenylalanine and glutamic acid | Metabolites | on-line | heart-cut | Cross-flow | RPLC | CE | LIF | Hooker et al. | 1997 |
| Polyesters, polyethers and macromers | Polymers | off-line | heart-cut | Manual | LCCC | SEC | MS | Krüger et al. | 1996 |
| Ethoxylated fatty alcohols | Surfactants | off-line | comprehensive | Manual | LCCC | SEC | RI | Trathnigg et al. | 1995 |
| Biological amines | Metabolites | on-line | heart-cut | Passive | SAX | RPLC | UV-vis | Holland et al. | 1995 |
| Ethoxylated fatty alcohols | Surfactants | off-line | comprehensive | Manual | LCCC | SEC | RI | Trathnigg et al. | 1994 |
| Peptide from rat brain tissue | Peptides | off-line | heart-cut | Manual | SAX | RPLC | UV-vis | Lundell et al. | 1992 |
| Plant extracts | Metabolites | on-line | heart-cut | Passive | SEC | RPLC | UV-vis | Erni and Frei | 1978 |
| Additives in cellulose acetate polymer | Miscellaneous | on-line | heart-cut | Passive | SEC | RPLC | UV-vis | Th. R. Floyd | 1988 |
| Protein mixtures | (Intact) Proteins | on-line | comprehensive | Passive | SCX | SEC | UV-vis | Bushey and Jorgenson | 1990 |
| Monoclonal antibodies | Biopharma | on-line | comprehensive | Passive | SEC | SEC | MS | Ehkirch et al. | 2018 |
| TCM (Flos Lonicerae Japonicae) | Natural medicines | off-line | comprehensive | Manual | HILIC | RPLC | MS, UV-vis | Zhao et al. | 2019 |
| Josamycin (degradation products and impurities) | Pharmaceuticals | on-line | mult. heart-cut | Passive | RPLC | RPLC | MS | Liu et al. | 2019 |
| Enoxaparins | Pharmaceuticals | on-line | mult. heart-cut | Passive | SEC | RPLC | MS | Ouyang et al. | 2019 |
| Acrylate-modified hyaluronic acid | Polymers | on-line | comprehensive | Passive | RPLC | SEC | ELSD | Viktor et al. | 2019 |
| Poly-1-octene (tacticity) | Polymers | on-line | comprehensive | Passive | RPLC | SEC | ELSD, RI, NMR | Rode et al. | 2019 |
| Metal-based anticancer drugs | Pharmaceuticals | on-line | heart-cut | Passive | SEC | RPLC | ICP-MS | Galvez et al. | 2019 |
| TCM (Arenaria kansuensis) | Natural medicines | off-line | heart-cut | Passive | RPLC | RPLC | UV-vis | Cui et al. | 2019 |
| Gluconic acid in honey samples | Food | on-line | heart-cut | Passive | SEC | RPLC | MS | Suto et al. | 2019 |
| tartary buckwheat (Fagopyrum tataricum) seeds | Peptides | off-line | heart-cut | Manual | RPLC | RPLC | MS | Wang et al. | 2019 |
| Lignocellulosic biomass products | Miscellaneous | off-line | comprehensive | Manual | CPC | RPLC | MS | Dubuis et al. | 2019 |
| Polyphenolic fraction of Pistacia vera L. kernel extracts | Food | on-line | comprehensive | Passive | RPLC | RPLC | MS | Arena et al. | 2019 |
| Monoterpene indole alkaloids in biological matrices | Food | on-line | heart-cut | Passive | SCX | RPLC | MS | Liu et al. | 2019 |
| Branching analysis of star-shaped polystyrenes | Polymers | on-line | comprehensive | Passive | TGIC | SEC | LS, RI, VI | Murima et al. | 2019 |
| Pesticide multi-screening | Environmental | on-line | mult. heart-cut | Passive | HILIC | RPLC | MS | Muehlwald et al. | 2019 |
| Drug metabolites | Pharmaceuticals | on-line | mult. heart-cut | SPAM | RPLC | RPLC | MS, UV-vis | Koppen et al. | 2019 |
| Pesticides | Environmental | on-line | mult. heart-cut | Passive | RPLC | RPLC | UV-vis | Pursch et al. | 2017 |
| Cytochrome C, carbonic anhydrase, beta-casein, beta-lactoglobulin, alpha-lactalbumin | Proteins | on-line | comprehensive | Passive | RPLC | RPLC | MS | Baghdady et al. | 2019 |
| Asn, Ser, Ala and Pro Enantiomers | Pharmaceuticals | on-line | 3DLC | Passive | RPLC | WAX | FLD | Furusho et al. | 2019 |
| Leucomycin (charactrization and impurity profiling) | Pharmaceuticals | on-line | mult. heart-cut | Passive | RPLC | RPLC | MS, UV-vis | Wang et al. | 2019 |
| Synthetic polymers (vinyl acetate/acrylic acid copolymers and vinyl acetate/itaconic acid/acrylic acid terpolymers) | Polymers | on-line | comprehensive | ASM | SEC | RPLC | ELSD | Yang et al. | 2019 |
| Aqueous-phase extracts of pyrolyzed bio-oils of different biomasses | Miscellaneous | on-line | comprehensive | Passive | RPLC | RPLC | MS, UV-vis | Lazzari et al. | 2019 |
| TCM (Flavonoid glycosides from Lobelia chinensis Lour) | Natural medicines | off-line | comprehensive | Manual | RPLC | HILIC | MS | Wang et al. | 2019 |
| Microalgae gastro-intestinal digests | Peptides | on-line | comprehensive | SPAM | HILIC | RPLC | MS | Sommella et al. | 2019 |
| TCM (bufadienolides in Venenum Bufonis) | Natural medicines | off-line | comprehensive | Manual | RPLC | SFC | UV-vis | Wei et al. | 2019 |
| Polycyclic Aromatic Hydrocarbons in Water Samples | Environmental | on-line | heart-cut | Passive | Affinity | RPLC | FLD | Armutcu et al. | 2019 |
| TCM (ginsenosides in Panax notoginseng leaves) | Natural medicines | on-line | comprehensive | SPAM | HILIC | RPLC | MS | Cao et al. | 2019 |
| Triazole fungicides in vegetables and fruits | Food | on-line | heart-cut | Passive | RPLC | Chiral | UV-vis | Zeng et al. | 2019 |
| Gangliosides profiling in swine brain extract | Lipids | off-line | comprehensive | Passive | SFC | RPLC | MS | Si et al. | 2019 |
| Therapeutic antibodies | Biopharma | on-line | comprehensive | ASM | RPLC | RPLC | MS | Stoll et al. | 2019 |
| TCM (Erzhi Pill, Ligustri Lucidi Fructus) | Natural medicines | off-line | comprehensive | Manual | HILIC | RPLC | MS | Fu et al. | 2019 |
| Impurities in mezlocillin sodium | Pharmaceuticals | on-line | mult. heart-cut | Passive | RPLC | RPLC | MS | Wang et al. | 2019 |
| TCM (ginsenosides from white and red ginsengs) | Natural medicines | on-line | comprehensive | SPAM | HILIC | RPLC | MS | Zhang et al. | 2019 |
| Pesticides, mycotoxins, tropane alkoloids, growth regulars in oats and whole wheat grains | Food | on-line | heart-cut | SPAM | HILIC | RPLC | MS | Urban et al. | 2019 |
| Enzyme kinetics of Ginkgo biloba leaves, rat liver microsomes | Metabolites | off-line | comprehensive | Manual | HILIC | RPLC | MS | Zheng et al. | 2019 |
| Posaconazole stereoisomers | Biopharma | on-line | mult. heart-cut | Passive | Chiral | Chiral | UV-vis | Xu et al. | 2020 |
| Screening of drug substances | Biopharma | on-line | comprehensive | Passive | SAX | RPLC | MS, UV-vis | Pickens et al. | 2020 |
| Benzophenone degradants after water chlorination | Environmental | on-line | heart-cut | Passive | RPLC | BMC | UV-vis | Li et al. | 2020 |
| Screening of drug substances | Biopharma | on-line | comprehensive | Passive | RPLC | RPLC | MS, UV-vis | Pickens et al. | 2020 |
| Screening of drug substances | Biopharma | on-line | comprehensive | Passive | SEC | RPLC | MS, UV-vis | Pickens et al. | 2020 |
| Valproic acid in human serum | Pharmaceuticals | on-line | heart-cut | Passive | RPLC | RPLC | UV-vis | Liu et al. | 2020 |
| Folic acid in human plasma | Metabolites | on-line | heart-cut | Passive | RPLC | RPLC | MS | Hyung et al. | 2020 |
| identification of modified nucleosides from RNA metabolism | Metabolites | on-line | comprehensive | Passive | RPLC | RPLC | MS | Willmann | 2020 |
| Metabolites from white ginseng and red ginseng | Metabolites | off-line | heart-cut | Manual | HILIC | RPLC | MS | Zuo et al. | 2020 |
| Microalgae (astaxanthin in Haematococcus pluvialis) | Food | on-line | comprehensive | Passive | NPLC | RPLC | MS, UV-vis | Gallego et al. | 2020 |
| Risperidone and 9-Hydroxyrisperidone in Human Serum | Biopharma | on-line | heart-cut | SPAM | SCX | RPLC | UV-vis | Liu et al. | 2020 |
| Phospholipids, cardiolipins | Lipids | on-line | heart-cut | Passive | HILIC | RPLC | MS | Helmer et al. | 2020 |
| Extracted pesticides and polar pesticides | Environmental | on-line | heart-cut | Passive | HILIC | RPLC | MS | Jost et al. | 2020 |
| Pharmaceuticals with multiple chiral centers | Biopharma | on-line | mult. heart-cut | Passive | RPLC | Chiral | UV-vis | Lin et al. | 2020 |
| Polyphenols in pomegranata, punica granatum L. | Food | on-line | comprehensive | Passive | RPLC | RPLC | MS, UV-vis | Russo et al. | 2020 |
| Aromatic amine oligomer | Miscellaneous | on-line | comprehensive | Passive | RPLC | RPLC | MS | Zhu et al. | 2020 |
| Lignocellulosic biomass products | Miscellaneous | off-line | comprehensive | Manual | SEC | RPLC | MS, UV-vis | Dubuis et al. | 2020 |
| Polar compounds | Metabolites | on-line | comprehensive | Passive | ZWIX | HILIC | CAD, MS, UV-vis | Bäurer et al. | 2020 |
| Lipidomics of human plasma | Lipids | on-line | heart-cut | VEM | NPLC | RPLC | MS | Yang et al. | 2020 |
| bovine serum albumin, human serum albumin, β-casein, α-chymotrypsinogen A, concanavalin A, cytochrome c | Intact Proteins | on-line | comprehensive | Passive | RPLC | RPLC | UV-vis | Wang et al. | 2020 |
| Impurities in dye-conjugated oligonucleotides | Biopharma | on-line | heart-cut | Passive | IP-RPLC | IP-RPLC | MS | Koshel et al. | 2020 |
| Aged plastic bonded explosives | Forensics | on-line | comprehensive | Passive | RPLC | SEC | UV-vis | Freye et al. | 2020 |
| Sulfur, vanadium and nickel compounds in petroleum products | Miscellaneous | off-line | comprehensive | Manual | SEC | RPLC | ICP-MS | Bernardin et al. | 2020 |
| Gangliosides in brain serum | Metabolites | off-line | comprehensive | Manual | SFC | RPLC | MS | Si et al. | 2020 |
| Proteins from soy flour samples | Intact Proteins | on-line | heart-cut | SPAM | SEC | RPLC | UV-vis | Nardiello et al. | 2020 |
| Monoclonal antibodies | Biopharma | on-line | mult. heart-cut | SPAM | Affinity | SEC | UV-vis | Wang et al. | 2020 |
| TCM (Lonicerae Japonicae Flos) | Natural medicines | off-line | comprehensive | Manual | HILIC | RPLC | MS | Pan et al. | 2020 |
| Metabolites in Brassica juncea Cultivars | Metabolites | on-line | comprehensive | Passive | RPLC | RPLC | UV-vis | Arena et al. | 2020 |
| Synthetic polymers (linear low‐density polyethylene resins) | Polymers | on-line | comprehensive | Passive | NPLC | SEC | ELSD | Sigwinta et al. | 2020 |
| Unknowns in industrial wastewater | Environmental | off-line | heart-cut | Manual | RPLC | RPLC | MS, UV-vis | Purschke et al. | 2020 |
| TCM (Buddleja davidii) | Natural medicines | on-line | comprehensive | ACD | RPLC | HILIC | MS | Chen et al. | 2020 |
| Monoclonal antibodies | Biopharma | on-line | mult. heart-cut | Passive | AEX | SEC | UV-vis | Chen et al. | 2020 |
| Microalgae peptidomics | Food | on-line | comprehensive | SPAM | HILIC | RPLC | MS, UV-vis | Sommella et al. | 2020 |
| Tryptic digest | Peptides | on-line | comprehensive | Passive | HILIC | RPLC | MS, UV-vis | Chapel et al. | 2020 |
| Impurities in rutin tablets | Food | on-line | mult. heart-cut | Passive | RPLC | RPLC | MS | Wang et al. | 2020 |
| Impurities in roxithromycin | Pharmaceuticals | on-line | heart-cut | Passive | RPLC | RPLC | MS | Wang et al. | 2020 |
| Mycotoxins in beer | Food | on-line | mult. heart-cut | Passive | RPLC | RPLC | MS | Campone et al. | 2020 |
| Polyphenolic fingerprints for classification of olive leaves and pulp extracts | Food | on-line | comprehensive | Passive | RPLC | RPLC | UV-vis | Vergara-Barberán et al. | 2020 |
| Hydroxyl radical footprinting analysis | Peptides | on-line | heart-cut | Passive | RPLC | RPLC | MS | Camperi et al. | 2020 |
| free sterols/stanols and steryl/stanyl esters in walnut | Food | on-line | heart-cut | Passive | RPLC | GC | MS | Apedo et al. | 2019 |
| TCM (toad skin, bufadienolides) | Natural medicines | on-line | comprehensive | VEM | NPLC | RPLC | UV-vis | Li et al. | 2017 |
| Antisense Oligonucleotide Impurities | Biopharma | on-line | mult. heart-cut | Passive | AEX | HILIC | MS | Goyon et al. | 2020 |
| Intact proteins | Intact Proteins | on-line | comprehensive | Passive | RPLC | RPLC | UV-vis | Wang et al. | 2020 |
| Phenolic fraction in extra virgin olive oils | Food | on-line | comprehensive | Passive | RPLC | RPLC | MS | Arena et al. | 2020 |
| Pesticides | Environmental | on-line | heart-cut | SPAM | HILIC | RPLC | MS | Jost et al. | 2020 |
| Posaconazole related stereoisomers | Biopharma | on-line | mult. heart-cut | Passive | Chiral | Chiral | UV | Xu et al. | 2020 |
| Cardiolipins and their oxidation products | Metabolites | on-line | mult. heart-cut | Passive | HILIC | RPLC | MS | Helmer et al. | 2020 |
| Emerging mycotoxins in Pu-erh tea | Food | on-line | heart-cut | Passive | RPLC | RPLC | MS | Bogdanova et al. | 2020 |
| Complex pharmaceutical samples | Biopharma | on-line | mult. heart-cut | Passive | RPLC | Chiral | UV-vis | Lin et al. | 2020 |
| Mixtures | Pharmaceuticals | on-line | mult. heart-cut | Passive | RPLC | Chiral | MS, UV-vis | Wang et al. | 2020 |
| Pesticide analysis | Environmental | on-line | heart-cut | Passive | HILIC | RPLC | MS | Muehlwald et al. | 2020 |
| Synthetic oligonucleotides | Biopharma | on-line | mult. heart-cut | Passive | MM | RPLC | MS | Li et al. | 2020 |
| Synthetic and therapeutic peptides | Biopharma | on-line | selective compr. | ASM | RPLC | RPLC | MS | Karongo et al. | 2020 |
| Pharmaceutical compounds | Pharmaceuticals | on-line | comprehensive | Passive | RPLC | RPLC | UV-vis | Aly et al. | 2020 |
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